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Atorvastatin with amlodipine brands ) and niacin-enriched milk fat (niacin beta carotene) have been administered. Both combinations minimal to no effects and are well tolerated. When given concurrently, however, statins are more protective. This may be due to the concomitant administration of beta carotene. Beta carotene from carrots was recently used to protect mice from retinoid toxicity and reduce retinoid-induced erythema. Vitamin A has been studied by feeding rabbits with β-carotene, and several clinical trials have been performed with beta carotene supplementation. As reported by one study, administration of β carotene to a population of 496 healthy rabbits at a concentration of 0.5 mg/kg body weight for 1 week resulted in a significant decrease of retinoic acid-induced retinal thickness. Another clinical study in healthy human volunteers receiving 40 to 200 mg/day of β carotene had an effect on skin phototypes, including erythema, and in normalizing retinoic acid-induced retinal thickening. In two separate controlled prospective trials, β carotene and vitamin C resulted in improved outcomes albino mice and in Japanese children with erythema caused by high-dose vitamin A (40,000 IUs/1 pound body weight) of prednisolone (600 mg). Vitamin E, the major polyunsaturated fat in plant foods, appears to have similar or lesser photoprotection as with its carotenoid counterpart β carotene. Beta-Carotene and Vitamin A in Human Health and Disease The health benefits of beta-carotene and vitamin A (retinoids) are well established. The most relevant health effect of beta-carotene is its powerful contribution for the prevention of skin aging. role retinoids in the prevention and treatment of various skin diseases (such as acne, psoriasis, rosacea, age spots, and hair loss) has only recently been researched. This article reviews the role played by vitamin A, beta-carotene, beta-cryptoxanthin, rhodopyran, pantothenic acid, and selenium in the prevention treatment of skin cancer, which is the number-one cause of cancer-related deaths in the United States. data indicate that the antioxidant effects of β-carotene and antioxidants are most important for early prevention of the development skin cancers. Longer-term studies on the roles of vitamin A, beta-carotene, and their interactions with the skin cells and mechanism of their roles in the maintenance of healthy skin may give us better insights into the mechanisms of UV-induced skin cancers. The effect of vitamin A for preventing skin aging is clearly shown in a study by Barger-Lux et al. in which vitamin A provided from green leafy vegetables in the diet increased levels of p53 in a Japanese population. The p53 was molecular marker of cell death and indicated the damage of DNA. A group headed by Leung et al., in their study on the relationship of skin cancer risk to UV exposure and vitamin D levels, found that the higher level of UV-induced sunlight exposure, the greater increase in skin cancer risk. A subsequent study by Wang et al. in which vitamin D supplementation augmented the decrease in risk of developing melanoma (the most lethal form of skin cancer) after repeated UV exposure atorvastatin generic coupons (UVB and UVA) demonstrated an increase in the risk for melanoma. In addition, vitamin A inhibits the proliferation of.
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